to extinguish or put out / to go out (of a fire etc) / to exterminate or wipe out / to drown
灭
=
一
+
火
:
In the elevator's bathroom (e4) Marilyn Monroe (mi) was playing the flute (一) so hot that it is on fire (火) now! Luckily there's a fire extinguisher so that she can put it out (灭).
失
=
𠂉
+
大
:
Sherlock (sh) locked himself out of the space station (Ø1)! He lost (失) his key (𠂉)! After he was floating in front of the space station for an eternity, a robot (大) came by with a lost+found box (失) which contained his lost key.